Cytotoxic guanidine alkaloids from Pterogyne nitens.
نویسندگان
چکیده
As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells.
منابع مشابه
Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens.
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عنوان ژورنال:
- Journal of natural products
دوره 72 3 شماره
صفحات -
تاریخ انتشار 2009